diff --git a/Marlin/Conditionals.h b/Marlin/Conditionals.h
index 41dcec76c3..c70c84ca70 100644
--- a/Marlin/Conditionals.h
+++ b/Marlin/Conditionals.h
@@ -395,10 +395,10 @@
   #endif
 
   /**
-   * Avoid double-negatives for enabling features
+   * Host keep alive
    */
-  #if DISABLED(DISABLE_HOST_KEEPALIVE)
-    #define HOST_KEEPALIVE_FEATURE
+  #ifndef DEFAULT_KEEPALIVE_INTERVAL
+    #define DEFAULT_KEEPALIVE_INTERVAL 2
   #endif
 
   /**
diff --git a/Marlin/Configuration.h b/Marlin/Configuration.h
index d9ceed5d58..18fe5c864a 100644
--- a/Marlin/Configuration.h
+++ b/Marlin/Configuration.h
@@ -733,13 +733,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE        // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2  // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/Felix/Configuration.h b/Marlin/example_configurations/Felix/Configuration.h
index 1449c56c2b..778ca60cb7 100644
--- a/Marlin/example_configurations/Felix/Configuration.h
+++ b/Marlin/example_configurations/Felix/Configuration.h
@@ -716,13 +716,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/Hephestos/Configuration.h b/Marlin/example_configurations/Hephestos/Configuration.h
index 1cd0b54767..b8ea32cedc 100644
--- a/Marlin/example_configurations/Hephestos/Configuration.h
+++ b/Marlin/example_configurations/Hephestos/Configuration.h
@@ -725,13 +725,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = true; // set to true to invert the lo
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/Hephestos_2/Configuration.h b/Marlin/example_configurations/Hephestos_2/Configuration.h
index 4f40633226..eaf556f3e2 100644
--- a/Marlin/example_configurations/Hephestos_2/Configuration.h
+++ b/Marlin/example_configurations/Hephestos_2/Configuration.h
@@ -727,13 +727,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/K8200/Configuration.h b/Marlin/example_configurations/K8200/Configuration.h
index ffba8b6d1a..8222877171 100644
--- a/Marlin/example_configurations/K8200/Configuration.h
+++ b/Marlin/example_configurations/K8200/Configuration.h
@@ -750,13 +750,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/RepRapWorld/Megatronics/Configuration.h b/Marlin/example_configurations/RepRapWorld/Megatronics/Configuration.h
index 19743c81a9..341097e0db 100644
--- a/Marlin/example_configurations/RepRapWorld/Megatronics/Configuration.h
+++ b/Marlin/example_configurations/RepRapWorld/Megatronics/Configuration.h
@@ -733,13 +733,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/RigidBot/Configuration.h b/Marlin/example_configurations/RigidBot/Configuration.h
index 36a0b73b45..ee68c80ad1 100644
--- a/Marlin/example_configurations/RigidBot/Configuration.h
+++ b/Marlin/example_configurations/RigidBot/Configuration.h
@@ -728,13 +728,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/SCARA/Configuration.h b/Marlin/example_configurations/SCARA/Configuration.h
index 71c17328d7..4394e5eabe 100644
--- a/Marlin/example_configurations/SCARA/Configuration.h
+++ b/Marlin/example_configurations/SCARA/Configuration.h
@@ -741,13 +741,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/TAZ4/Configuration.h b/Marlin/example_configurations/TAZ4/Configuration.h
index 303168d5ba..39c71527e8 100644
--- a/Marlin/example_configurations/TAZ4/Configuration.h
+++ b/Marlin/example_configurations/TAZ4/Configuration.h
@@ -754,13 +754,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/WITBOX/Configuration.h b/Marlin/example_configurations/WITBOX/Configuration.h
index ee42247d3e..1c48ddd18e 100644
--- a/Marlin/example_configurations/WITBOX/Configuration.h
+++ b/Marlin/example_configurations/WITBOX/Configuration.h
@@ -725,13 +725,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = true; // set to true to invert the lo
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/adafruit/ST7565/Configuration.h b/Marlin/example_configurations/adafruit/ST7565/Configuration.h
index c41e92a8af..a115f3c138 100644
--- a/Marlin/example_configurations/adafruit/ST7565/Configuration.h
+++ b/Marlin/example_configurations/adafruit/ST7565/Configuration.h
@@ -733,13 +733,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/delta/biv2.5/Configuration.h b/Marlin/example_configurations/delta/biv2.5/Configuration.h
index cb6a89a6cd..adc1b0d739 100644
--- a/Marlin/example_configurations/delta/biv2.5/Configuration.h
+++ b/Marlin/example_configurations/delta/biv2.5/Configuration.h
@@ -862,13 +862,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = true; // set to true to invert the lo
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/delta/generic/Configuration.h b/Marlin/example_configurations/delta/generic/Configuration.h
index 2456e95cd5..954854eb4e 100644
--- a/Marlin/example_configurations/delta/generic/Configuration.h
+++ b/Marlin/example_configurations/delta/generic/Configuration.h
@@ -862,13 +862,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = true; // set to true to invert the lo
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/delta/kossel_mini/Configuration.h b/Marlin/example_configurations/delta/kossel_mini/Configuration.h
index 3493d7cefd..c4f3ffcd99 100644
--- a/Marlin/example_configurations/delta/kossel_mini/Configuration.h
+++ b/Marlin/example_configurations/delta/kossel_mini/Configuration.h
@@ -866,13 +866,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/delta/kossel_pro/Configuration.h b/Marlin/example_configurations/delta/kossel_pro/Configuration.h
index 95e872d3a2..c977b47c3a 100644
--- a/Marlin/example_configurations/delta/kossel_pro/Configuration.h
+++ b/Marlin/example_configurations/delta/kossel_pro/Configuration.h
@@ -859,13 +859,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/delta/kossel_xl/Configuration.h b/Marlin/example_configurations/delta/kossel_xl/Configuration.h
index fb65e71d2c..e2d277fa46 100644
--- a/Marlin/example_configurations/delta/kossel_xl/Configuration.h
+++ b/Marlin/example_configurations/delta/kossel_xl/Configuration.h
@@ -867,13 +867,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/makibox/Configuration.h b/Marlin/example_configurations/makibox/Configuration.h
index f647f125ad..7da67eb865 100644
--- a/Marlin/example_configurations/makibox/Configuration.h
+++ b/Marlin/example_configurations/makibox/Configuration.h
@@ -736,13 +736,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/tvrrug/Round2/Configuration.h b/Marlin/example_configurations/tvrrug/Round2/Configuration.h
index bf192eea8f..83b64f70da 100644
--- a/Marlin/example_configurations/tvrrug/Round2/Configuration.h
+++ b/Marlin/example_configurations/tvrrug/Round2/Configuration.h
@@ -727,13 +727,11 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = true; // set to true to invert the lo
 //
 // Host Keepalive
 //
-// By default Marlin will send a busy status message to the host
+// When enabled Marlin will send a busy status message to the host
 // every couple of seconds when it can't accept commands.
 //
-//#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
-#if DISABLED(DISABLE_HOST_KEEPALIVE)
-  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
-#endif
+#define HOST_KEEPALIVE_FEATURE       // Disable this if your host doesn't like keepalive messages
+#define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
 
 //
 // M100 Free Memory Watcher