diff --git a/Marlin/Configuration.h b/Marlin/Configuration.h
index 8f530369e3..7caceac2ee 100644
--- a/Marlin/Configuration.h
+++ b/Marlin/Configuration.h
@@ -342,6 +342,7 @@
   #define MIXING_VIRTUAL_TOOLS 16  // Use the Virtual Tool method with M163 and M164
   //#define DIRECT_MIXING_IN_G1    // Allow ABCDHI mix factors in G1 movement commands
   //#define GRADIENT_MIX           // Support for gradient mixing with M166 and LCD
+  //#define MIXING_PRESETS         // Assign 8 default V-tool presets for 2 or 3 MIXING_STEPPERS
   #if ENABLED(GRADIENT_MIX)
     //#define GRADIENT_VTOOL       // Add M166 T to use a V-tool index as a Gradient alias
   #endif
diff --git a/Marlin/src/feature/mixing.cpp b/Marlin/src/feature/mixing.cpp
index 4823ac2c60..332a4f3740 100644
--- a/Marlin/src/feature/mixing.cpp
+++ b/Marlin/src/feature/mixing.cpp
@@ -106,11 +106,32 @@ void Mixer::reset_vtools() {
       MIXER_STEPPER_LOOP(i)
         color[t][i] = (i == 0) ? COLOR_A_MASK : 0;
   #endif
+
+  // MIXING_PRESETS: Set a variety of obvious mixes as presets
+  #if ENABLED(MIXING_PRESETS) && WITHIN(MIXING_STEPPERS, 2, 3)
+    #if MIXING_STEPPERS == 2
+      if (MIXING_VIRTUAL_TOOLS > 2) { collector[0] = 1; collector[1] = 1; mixer.normalize(2); } // 1:1
+      if (MIXING_VIRTUAL_TOOLS > 3) { collector[0] = 3;                   mixer.normalize(3); } // 3:1
+      if (MIXING_VIRTUAL_TOOLS > 4) { collector[0] = 1; collector[1] = 3; mixer.normalize(4); } // 1:3
+      if (MIXING_VIRTUAL_TOOLS > 5) {                   collector[1] = 2; mixer.normalize(5); } // 1:2
+      if (MIXING_VIRTUAL_TOOLS > 6) { collector[0] = 2; collector[1] = 1; mixer.normalize(6); } // 2:1
+      if (MIXING_VIRTUAL_TOOLS > 7) { collector[0] = 3; collector[1] = 2; mixer.normalize(7); } // 3:2
+    #else
+      if (MIXING_VIRTUAL_TOOLS > 3) { collector[0] = 1; collector[1] = 1; collector[2] = 1; mixer.normalize(3); } // 1:1:1
+      if (MIXING_VIRTUAL_TOOLS > 4) {                   collector[1] = 3; collector[2] = 0; mixer.normalize(4); } // 1:3:0
+      if (MIXING_VIRTUAL_TOOLS > 5) { collector[0] = 0;                   collector[2] = 1; mixer.normalize(5); } // 0:3:1
+      if (MIXING_VIRTUAL_TOOLS > 6) {                   collector[1] = 1;                   mixer.normalize(6); } // 0:1:1
+      if (MIXING_VIRTUAL_TOOLS > 7) { collector[0] = 1;                   collector[2] = 0; mixer.normalize(7); } // 1:1:0
+    #endif
+    ZERO(collector);
+  #endif
 }
 
 // called at boot
 void Mixer::init() {
 
+  ZERO(collector);
+
   reset_vtools();
 
   #if HAS_MIXER_SYNC_CHANNEL
@@ -119,8 +140,6 @@ void Mixer::init() {
       color[MIXER_AUTORETRACT_TOOL][i] = COLOR_A_MASK;
   #endif
 
-  ZERO(collector);
-
   #if EITHER(HAS_DUAL_MIXING, GRADIENT_MIX)
     update_mix_from_vtool();
   #endif