diff --git a/Marlin/src/inc/SanityCheck.h b/Marlin/src/inc/SanityCheck.h
index 072bb26bfe..0dfa305841 100644
--- a/Marlin/src/inc/SanityCheck.h
+++ b/Marlin/src/inc/SanityCheck.h
@@ -2006,6 +2006,8 @@ static_assert(hbm[Z_AXIS] >= 0, "HOMING_BUMP_MM.Z must be greater than or equal
   #error "Enable USE_ZMIN_PLUG when homing Z to MIN."
 #elif Z_HOME_DIR > 0 && ENABLED(USE_PROBE_FOR_Z_HOMING)
   #error "Z_HOME_DIR must be -1 when homing Z with the probe."
+#elif BOTH(HOMING_Z_WITH_PROBE, Z_MULTI_ENDSTOPS)
+  #error "Z_MULTI_ENDSTOPS is incompatible with USE_PROBE_FOR_Z_HOMING."
 #elif Z_HOME_DIR > 0 && DISABLED(USE_ZMAX_PLUG)
   #error "Enable USE_ZMAX_PLUG when homing Z to MAX."
 #endif
diff --git a/buildroot/tests/DUE-tests b/buildroot/tests/DUE-tests
index ccb49bf482..009688ce21 100755
--- a/buildroot/tests/DUE-tests
+++ b/buildroot/tests/DUE-tests
@@ -41,14 +41,9 @@ exec_test $1 $2 "RAMPS4DUE_EFB with ABL (Bilinear), ExtUI, S-Curve, many options
 restore_configs
 opt_set MOTHERBOARD BOARD_RADDS
 opt_enable USE_XMAX_PLUG USE_YMAX_PLUG ENDSTOPPULLUPS BLTOUCH AUTO_BED_LEVELING_BILINEAR \
-           Z_MULTI_ENDSTOPS Z_STEPPER_AUTO_ALIGN Z_STEPPER_ALIGN_KNOWN_STEPPER_POSITIONS \
-           Z_SAFE_HOMING
+           Z_STEPPER_AUTO_ALIGN Z_STEPPER_ALIGN_KNOWN_STEPPER_POSITIONS Z_SAFE_HOMING
            #TOUCH_UI_FTDI_EVE LCD_ALEPHOBJECTS_CLCD_UI OTHER_PIN_LAYOUT
 opt_set NUM_Z_STEPPER_DRIVERS 3
-opt_add Z2_MAX_ENDSTOP_INVERTING false
-opt_add Z3_MAX_ENDSTOP_INVERTING false
-opt_add Z2_MAX_PIN 2
-opt_add Z3_MAX_PIN 3
 pins_set ramps/RAMPS X_MAX_PIN -1
 pins_set ramps/RAMPS Y_MAX_PIN -1
 exec_test $1 $2 "RADDS with ABL (Bilinear), Triple Z Axis, Z_STEPPER_AUTO_ALIGN" "$3"