diff --git a/Marlin/src/MarlinCore.cpp b/Marlin/src/MarlinCore.cpp
index e91b3f091c..3d1ce1d383 100644
--- a/Marlin/src/MarlinCore.cpp
+++ b/Marlin/src/MarlinCore.cpp
@@ -965,7 +965,6 @@ void setup() {
     #endif
   #endif
 
-  #if NUM_SERIAL > 0
     MYSERIAL0.begin(USB_BAUDRATE);
     uint32_t serial_connect_timeout = millis() + 1000UL;
     while (!MYSERIAL0 && PENDING(millis(), serial_connect_timeout)) { /*nada*/ }
@@ -975,7 +974,6 @@ void setup() {
       while (!MYSERIAL1 && PENDING(millis(), serial_connect_timeout)) { /*nada*/ }
     #endif
     SERIAL_ECHO_MSG("start");
-#endif
 
   #if BOTH(HAS_TFT_LVGL_UI, USE_WIFI_FUNCTION)
     mks_esp_wifi_init();