diff --git a/Marlin/src/inc/SanityCheck.h b/Marlin/src/inc/SanityCheck.h
index 7313a140c3..8d4b9d33bd 100644
--- a/Marlin/src/inc/SanityCheck.h
+++ b/Marlin/src/inc/SanityCheck.h
@@ -2462,8 +2462,8 @@ static_assert(Y_MAX_LENGTH >= Y_BED_SIZE, "Movement bounds (Y_MIN_POS, Y_MAX_POS
 #if HAS_I2C_DIGIPOT
   #if BOTH(DIGIPOT_MCP4018, DIGIPOT_MCP4451)
     #error "Enable only one of DIGIPOT_MCP4018 or DIGIPOT_MCP4451."
-  #elif !defined(DIGIPOTS_I2C_SDA_X) || !defined(DIGIPOTS_I2C_SDA_Y) || !defined(DIGIPOTS_I2C_SDA_Z) \
-    || !defined(DIGIPOTS_I2C_SDA_E0) || !defined(DIGIPOTS_I2C_SDA_E1)
+  #elif !MB(MKS_SBASE) \
+    && (!defined(DIGIPOTS_I2C_SDA_X) || !defined(DIGIPOTS_I2C_SDA_Y) || !defined(DIGIPOTS_I2C_SDA_Z) || !defined(DIGIPOTS_I2C_SDA_E0) || !defined(DIGIPOTS_I2C_SDA_E1))
       #error "DIGIPOT_MCP4018/4451 requires DIGIPOTS_I2C_SDA_* pins to be defined."
   #endif
 #endif