diff --git a/Marlin/src/HAL/shared/I2cEeprom.cpp b/Marlin/src/HAL/shared/I2cEeprom.cpp
index 9d295c4b83..ef2ff8222f 100644
--- a/Marlin/src/HAL/shared/I2cEeprom.cpp
+++ b/Marlin/src/HAL/shared/I2cEeprom.cpp
@@ -87,7 +87,7 @@ void eeprom_write_byte(uint8_t *pos, unsigned char value) {
 
   eeprom_init();
 
-  Wire.beginTransmission(eeprom_device_address);
+  Wire.beginTransmission(I2C_ADDRESS(eeprom_device_address));
   Wire.write((int)(eeprom_address >> 8));   // MSB
   Wire.write((int)(eeprom_address & 0xFF)); // LSB
   Wire.write(value);
@@ -103,7 +103,7 @@ void eeprom_write_byte(uint8_t *pos, unsigned char value) {
 void eeprom_update_block(const void *pos, void* eeprom_address, size_t n) {
   eeprom_init();
 
-  Wire.beginTransmission(eeprom_device_address);
+  Wire.beginTransmission(I2C_ADDRESS(eeprom_device_address));
   Wire.write((int)((unsigned)eeprom_address >> 8));   // MSB
   Wire.write((int)((unsigned)eeprom_address & 0xFF)); // LSB
   Wire.endTransmission();
@@ -115,7 +115,7 @@ void eeprom_update_block(const void *pos, void* eeprom_address, size_t n) {
     flag |= Wire.read() ^ ptr[c];
 
   if (flag) {
-    Wire.beginTransmission(eeprom_device_address);
+    Wire.beginTransmission(I2C_ADDRESS(eeprom_device_address));
     Wire.write((int)((unsigned)eeprom_address >> 8));   // MSB
     Wire.write((int)((unsigned)eeprom_address & 0xFF)); // LSB
     Wire.write((uint8_t*)pos, n);
@@ -133,7 +133,7 @@ uint8_t eeprom_read_byte(uint8_t *pos) {
 
   eeprom_init();
 
-  Wire.beginTransmission(eeprom_device_address);
+  Wire.beginTransmission(I2C_ADDRESS(eeprom_device_address));
   Wire.write((int)(eeprom_address >> 8));   // MSB
   Wire.write((int)(eeprom_address & 0xFF)); // LSB
   Wire.endTransmission();
@@ -145,7 +145,7 @@ uint8_t eeprom_read_byte(uint8_t *pos) {
 void eeprom_read_block(void* pos, const void* eeprom_address, size_t n) {
   eeprom_init();
 
-  Wire.beginTransmission(eeprom_device_address);
+  Wire.beginTransmission(I2C_ADDRESS(eeprom_device_address));
   Wire.write((int)((unsigned)eeprom_address >> 8));   // MSB
   Wire.write((int)((unsigned)eeprom_address & 0xFF)); // LSB
   Wire.endTransmission();
diff --git a/Marlin/src/core/macros.h b/Marlin/src/core/macros.h
index 009a7f7b85..b438db9201 100644
--- a/Marlin/src/core/macros.h
+++ b/Marlin/src/core/macros.h
@@ -229,3 +229,9 @@
 #define LROUND(x)   lroundf(x)
 #define FMOD(x, y)  fmodf(x, y)
 #define HYPOT(x,y)  SQRT(HYPOT2(x,y))
+
+#ifdef TARGET_LPC1768
+  #define I2C_ADDRESS(A) ((A) << 1)
+#else
+  #define I2C_ADDRESS(A) A
+#endif
diff --git a/Marlin/src/feature/I2CPositionEncoder.cpp b/Marlin/src/feature/I2CPositionEncoder.cpp
index 3ada505dc9..f83ac8e3d4 100644
--- a/Marlin/src/feature/I2CPositionEncoder.cpp
+++ b/Marlin/src/feature/I2CPositionEncoder.cpp
@@ -473,7 +473,7 @@ void I2CPositionEncoder::calibrate_steps_mm(const uint8_t iter) {
 }
 
 void I2CPositionEncoder::reset() {
-  Wire.beginTransmission(i2cAddress);
+  Wire.beginTransmission(I2C_ADDRESS(i2cAddress));
   Wire.write(I2CPE_RESET_COUNT);
   Wire.endTransmission();
 
@@ -703,7 +703,7 @@ void I2CPositionEncodersMgr::report_position(const int8_t idx, const bool units,
 
 void I2CPositionEncodersMgr::change_module_address(const uint8_t oldaddr, const uint8_t newaddr) {
   // First check 'new' address is not in use
-  Wire.beginTransmission(newaddr);
+  Wire.beginTransmission(I2C_ADDRESS(newaddr));
   if (!Wire.endTransmission()) {
     SERIAL_ECHOPAIR("?There is already a device with that address on the I2C bus! (", newaddr);
     SERIAL_ECHOLNPGM(")");
@@ -711,7 +711,7 @@ void I2CPositionEncodersMgr::change_module_address(const uint8_t oldaddr, const
   }
 
   // Now check that we can find the module on the oldaddr address
-  Wire.beginTransmission(oldaddr);
+  Wire.beginTransmission(I2C_ADDRESS(oldaddr));
   if (Wire.endTransmission()) {
     SERIAL_ECHOPAIR("?No module detected at this address! (", oldaddr);
     SERIAL_ECHOLNPGM(")");
@@ -722,7 +722,7 @@ void I2CPositionEncodersMgr::change_module_address(const uint8_t oldaddr, const
   SERIAL_ECHOLNPAIR(", changing address to ", newaddr);
 
   // Change the modules address
-  Wire.beginTransmission(oldaddr);
+  Wire.beginTransmission(I2C_ADDRESS(oldaddr));
   Wire.write(I2CPE_SET_ADDR);
   Wire.write(newaddr);
   Wire.endTransmission();
@@ -733,7 +733,7 @@ void I2CPositionEncodersMgr::change_module_address(const uint8_t oldaddr, const
   safe_delay(I2CPE_REBOOT_TIME);
 
   // Look for the module at the new address.
-  Wire.beginTransmission(newaddr);
+  Wire.beginTransmission(I2C_ADDRESS(newaddr));
   if (Wire.endTransmission()) {
     SERIAL_ECHOLNPGM("Address change failed! Check encoder module.");
     return;
@@ -753,7 +753,7 @@ void I2CPositionEncodersMgr::change_module_address(const uint8_t oldaddr, const
 
 void I2CPositionEncodersMgr::report_module_firmware(const uint8_t address) {
   // First check there is a module
-  Wire.beginTransmission(address);
+  Wire.beginTransmission(I2C_ADDRESS(address));
   if (Wire.endTransmission()) {
     SERIAL_ECHOPAIR("?No module detected at this address! (", address);
     SERIAL_ECHOLNPGM(")");
@@ -763,7 +763,7 @@ void I2CPositionEncodersMgr::report_module_firmware(const uint8_t address) {
   SERIAL_ECHOPAIR("Requesting version info from module at address ", address);
   SERIAL_ECHOLNPGM(":");
 
-  Wire.beginTransmission(address);
+  Wire.beginTransmission(I2C_ADDRESS(address));
   Wire.write(I2CPE_SET_REPORT_MODE);
   Wire.write(I2CPE_REPORT_VERSION);
   Wire.endTransmission();
@@ -777,7 +777,7 @@ void I2CPositionEncodersMgr::report_module_firmware(const uint8_t address) {
   }
 
   // Set module back to normal (distance) mode
-  Wire.beginTransmission(address);
+  Wire.beginTransmission(I2C_ADDRESS(address));
   Wire.write(I2CPE_SET_REPORT_MODE);
   Wire.write(I2CPE_REPORT_DISTANCE);
   Wire.endTransmission();
diff --git a/Marlin/src/feature/dac/dac_mcp4728.cpp b/Marlin/src/feature/dac/dac_mcp4728.cpp
index 9798bbc330..689be54f96 100644
--- a/Marlin/src/feature/dac/dac_mcp4728.cpp
+++ b/Marlin/src/feature/dac/dac_mcp4728.cpp
@@ -69,7 +69,7 @@ uint8_t mcp4728_analogWrite(uint8_t channel, uint16_t value) {
  * This will also write current Vref, PowerDown, Gain settings to EEPROM
  */
 uint8_t mcp4728_eepromWrite() {
-  Wire.beginTransmission(DAC_DEV_ADDRESS);
+  Wire.beginTransmission(I2C_ADDRESS(DAC_DEV_ADDRESS));
   Wire.write(SEQWRITE);
   LOOP_XYZE(i) {
     Wire.write(DAC_STEPPER_VREF << 7 | DAC_STEPPER_GAIN << 4 | highByte(mcp4728_values[i]));
@@ -82,7 +82,7 @@ uint8_t mcp4728_eepromWrite() {
  * Write Voltage reference setting to all input regiters
  */
 uint8_t mcp4728_setVref_all(uint8_t value) {
-  Wire.beginTransmission(DAC_DEV_ADDRESS);
+  Wire.beginTransmission(I2C_ADDRESS(DAC_DEV_ADDRESS));
   Wire.write(VREFWRITE | (value ? 0x0F : 0x00));
   return Wire.endTransmission();
 }
@@ -90,7 +90,7 @@ uint8_t mcp4728_setVref_all(uint8_t value) {
  * Write Gain setting to all input regiters
  */
 uint8_t mcp4728_setGain_all(uint8_t value) {
-  Wire.beginTransmission(DAC_DEV_ADDRESS);
+  Wire.beginTransmission(I2C_ADDRESS(DAC_DEV_ADDRESS));
   Wire.write(GAINWRITE | (value ? 0x0F : 0x00));
   return Wire.endTransmission();
 }
@@ -133,7 +133,7 @@ void mcp4728_setDrvPct(uint8_t pct[XYZE]) {
  * No EEPROM update
  */
 uint8_t mcp4728_fastWrite() {
-  Wire.beginTransmission(DAC_DEV_ADDRESS);
+  Wire.beginTransmission(I2C_ADDRESS(DAC_DEV_ADDRESS));
   LOOP_XYZE(i) {
     Wire.write(highByte(mcp4728_values[i]));
     Wire.write(lowByte(mcp4728_values[i]));
@@ -145,7 +145,7 @@ uint8_t mcp4728_fastWrite() {
  * Common function for simple general commands
  */
 uint8_t mcp4728_simpleCommand(byte simpleCommand) {
-  Wire.beginTransmission(GENERALCALL);
+  Wire.beginTransmission(I2C_ADDRESS(GENERALCALL));
   Wire.write(simpleCommand);
   return Wire.endTransmission();
 }
diff --git a/Marlin/src/feature/digipot/digipot_mcp4451.cpp b/Marlin/src/feature/digipot/digipot_mcp4451.cpp
index 1036196383..6e02a1607c 100644
--- a/Marlin/src/feature/digipot/digipot_mcp4451.cpp
+++ b/Marlin/src/feature/digipot/digipot_mcp4451.cpp
@@ -50,7 +50,7 @@ static void i2c_send(const byte addr, const byte a, const byte b) {
     digipot_mcp4451_send_byte(a);
     digipot_mcp4451_send_byte(b);
   #else
-    Wire.beginTransmission(addr);
+    Wire.beginTransmission(I2C_ADDRESS(addr));
     Wire.write(a);
     Wire.write(b);
     Wire.endTransmission();
diff --git a/Marlin/src/feature/leds/blinkm.cpp b/Marlin/src/feature/leds/blinkm.cpp
index 44390cc1e6..f994f9026c 100644
--- a/Marlin/src/feature/leds/blinkm.cpp
+++ b/Marlin/src/feature/leds/blinkm.cpp
@@ -34,7 +34,7 @@
 
 void blinkm_set_led_color(const LEDColor &color) {
   Wire.begin();
-  Wire.beginTransmission(0x09);
+  Wire.beginTransmission(I2C_ADDRESS(0x09));
   Wire.write('o');                    //to disable ongoing script, only needs to be used once
   Wire.write('n');
   Wire.write(color.r);
diff --git a/Marlin/src/feature/leds/pca9632.cpp b/Marlin/src/feature/leds/pca9632.cpp
index 8073ae136f..d32fcd01c9 100644
--- a/Marlin/src/feature/leds/pca9632.cpp
+++ b/Marlin/src/feature/leds/pca9632.cpp
@@ -74,14 +74,14 @@
 byte PCA_init = 0;
 
 static void PCA9632_WriteRegister(const byte addr, const byte regadd, const byte value) {
-  Wire.beginTransmission(addr);
+  Wire.beginTransmission(I2C_ADDRESS(addr));
   Wire.write(regadd);
   Wire.write(value);
   Wire.endTransmission();
 }
 
 static void PCA9632_WriteAllRegisters(const byte addr, const byte regadd, const byte value1, const byte value2, const byte value3) {
-  Wire.beginTransmission(addr);
+  Wire.beginTransmission(I2C_ADDRESS(addr));
   Wire.write(PCA9632_AUTO_IND | regadd);
   Wire.write(value1);
   Wire.write(value2);
@@ -91,7 +91,7 @@ static void PCA9632_WriteAllRegisters(const byte addr, const byte regadd, const
 
 #if 0
   static byte PCA9632_ReadRegister(const byte addr, const byte regadd) {
-    Wire.beginTransmission(addr);
+    Wire.beginTransmission(I2C_ADDRESS(addr));
     Wire.write(regadd);
     const byte value = Wire.read();
     Wire.endTransmission();
diff --git a/Marlin/src/feature/twibus.cpp b/Marlin/src/feature/twibus.cpp
index 84fcc1e8f5..6913284d33 100644
--- a/Marlin/src/feature/twibus.cpp
+++ b/Marlin/src/feature/twibus.cpp
@@ -81,7 +81,7 @@ void TWIBus::send() {
     debug(PSTR("send"), this->addr);
   #endif
 
-  Wire.beginTransmission(this->addr);
+  Wire.beginTransmission(I2C_ADDRESS(this->addr));
   Wire.write(this->buffer, this->buffer_s);
   Wire.endTransmission();