diff --git a/Marlin/SanityCheck.h b/Marlin/SanityCheck.h
index f6c7245a2d..fc1f75f529 100644
--- a/Marlin/SanityCheck.h
+++ b/Marlin/SanityCheck.h
@@ -396,6 +396,8 @@
     #error "Please select either MIXING_EXTRUDER or SWITCHING_EXTRUDER, not both."
   #elif ENABLED(SINGLENOZZLE)
     #error "MIXING_EXTRUDER is incompatible with SINGLENOZZLE."
+  #elif ENABLED(LIN_ADVANCE)
+    #error "MIXING_EXTRUDER is incompatible with LIN_ADVANCE."
   #endif
 #endif