diff --git a/Marlin/src/inc/SanityCheck.h b/Marlin/src/inc/SanityCheck.h
index a94846275e..864f759982 100644
--- a/Marlin/src/inc/SanityCheck.h
+++ b/Marlin/src/inc/SanityCheck.h
@@ -1157,6 +1157,8 @@ static_assert(Y_MAX_LENGTH >= Y_BED_SIZE, "Movement bounds (Y_MIN_POS, Y_MAX_POS
     #error "SWITCHING_NOZZLE and DUAL_X_CARRIAGE are incompatible."
   #elif ENABLED(SINGLENOZZLE)
     #error "SWITCHING_NOZZLE and SINGLENOZZLE are incompatible."
+  #elif HAS_PRUSA_MMU2
+    #error "SWITCHING_NOZZLE and PRUSA_MMU2(S) are incompatible."
   #elif EXTRUDERS != 2
     #error "SWITCHING_NOZZLE requires exactly 2 EXTRUDERS."
   #elif NUM_SERVOS < 1