diff --git a/Marlin/Configuration.h b/Marlin/Configuration.h
index e976d64c52..6d38e833cc 100644
--- a/Marlin/Configuration.h
+++ b/Marlin/Configuration.h
@@ -35,7 +35,7 @@
  *
  * Advanced settings can be found in Configuration_adv.h
  */
-#define CONFIGURATION_H_VERSION 02000904
+#define CONFIGURATION_H_VERSION 02010000
 
 //===========================================================================
 //============================= Getting Started =============================
diff --git a/Marlin/Configuration_adv.h b/Marlin/Configuration_adv.h
index 48852f62dc..16a4f36e4f 100644
--- a/Marlin/Configuration_adv.h
+++ b/Marlin/Configuration_adv.h
@@ -30,7 +30,7 @@
  *
  * Basic settings can be found in Configuration.h
  */
-#define CONFIGURATION_ADV_H_VERSION 02000904
+#define CONFIGURATION_ADV_H_VERSION 02010000
 
 //===========================================================================
 //============================= Thermal Settings ============================
diff --git a/Marlin/Version.h b/Marlin/Version.h
index 68d56f6e7e..f6e4635c8f 100644
--- a/Marlin/Version.h
+++ b/Marlin/Version.h
@@ -28,7 +28,7 @@
 /**
  * Marlin release version identifier
  */
-//#define SHORT_BUILD_VERSION "2.0.9.4"
+//#define SHORT_BUILD_VERSION "2.1"
 
 /**
  * Verbose version identifier which should contain a reference to the location
diff --git a/Marlin/src/inc/Version.h b/Marlin/src/inc/Version.h
index f7d5e1774c..4070a801a5 100644
--- a/Marlin/src/inc/Version.h
+++ b/Marlin/src/inc/Version.h
@@ -25,7 +25,7 @@
  * Release version. Leave the Marlin version or apply a custom scheme.
  */
 #ifndef SHORT_BUILD_VERSION
-  #define SHORT_BUILD_VERSION "2.0.9.4"
+  #define SHORT_BUILD_VERSION "2.1"
 #endif
 
 /**
@@ -52,7 +52,7 @@
  * to alert users to major changes.
  */
 
-#define MARLIN_HEX_VERSION 02000904
+#define MARLIN_HEX_VERSION 02010000
 #ifndef REQUIRED_CONFIGURATION_H_VERSION
   #define REQUIRED_CONFIGURATION_H_VERSION MARLIN_HEX_VERSION
 #endif
diff --git a/README.md b/README.md
index e54c8f093a..3b0268caf5 100644
--- a/README.md
+++ b/README.md
@@ -15,9 +15,9 @@
 Additional documentation can be found at the [Marlin Home Page](https://marlinfw.org/).
 Please test this firmware and let us know if it misbehaves in any way. Volunteers are standing by!
 
-## Marlin 2.0
+## Marlin 2.1
 
-Marlin 2.0 takes this popular RepRap firmware to the next level by adding support for much faster 32-bit and ARM-based boards while improving support for 8-bit AVR boards. Read about Marlin's decision to use a "Hardware Abstraction Layer" below.
+Marlin 2.1 continues to support both 32-bit ARM and 8-bit AVR boards while adding support for up to 9 coordinated axes and to up to 8 extruders.
 
 Download earlier versions of Marlin on the [Releases page](https://github.com/MarlinFirmware/Marlin/releases).
 
@@ -25,9 +25,9 @@ Download earlier versions of Marlin on the [Releases page](https://github.com/Ma
 
 Before building Marlin you'll need to configure it for your specific hardware. Your vendor should have already provided source code with configurations for the installed firmware, but if you ever decide to upgrade you'll need updated configuration files. Marlin users have contributed dozens of tested example configurations to get you started. Visit the [MarlinFirmware/Configurations](https://github.com/MarlinFirmware/Configurations) repository to find the right configuration for your hardware.
 
-## Building Marlin 2.0
+## Building Marlin 2.1
 
-To build Marlin 2.0 you'll need [Arduino IDE 1.8.8 or newer](https://www.arduino.cc/en/main/software) or [PlatformIO](http://docs.platformio.org/en/latest/ide.html#platformio-ide). Detailed build and install instructions are posted at:
+To build Marlin 2.1 you'll need [Arduino IDE 1.8.8 or newer](https://www.arduino.cc/en/main/software) or [PlatformIO](http://docs.platformio.org/en/latest/ide.html#platformio-ide). Detailed build and install instructions are posted at:
 
   - [Installing Marlin (Arduino)](http://marlinfw.org/docs/basics/install_arduino.html)
   - [Installing Marlin (VSCode)](http://marlinfw.org/docs/basics/install_platformio_vscode.html).
@@ -52,9 +52,9 @@ To build Marlin 2.0 you'll need [Arduino IDE 1.8.8 or newer](https://www.arduino
   [Teensy 4.1](https://www.pjrc.com/store/teensy41.html)|ARM® Cortex-M7|
   Linux Native|x86/ARM/etc.|Raspberry Pi
 
-## Submitting Changes
+## Submitting Patches
 
-- Submit **Bug Fixes** as Pull Requests to the ([bugfix-2.0.x](https://github.com/MarlinFirmware/Marlin/tree/bugfix-2.0.x)) branch.
+- Submit **Bug Fixes** as Pull Requests to the ([bugfix-2.1.x](https://github.com/MarlinFirmware/Marlin/tree/bugfix-2.1.x)) branch.
 - Follow the [Coding Standards](http://marlinfw.org/docs/development/coding_standards.html) to gain points with the maintainers.
 - Please submit your questions and concerns to the [Issue Queue](https://github.com/MarlinFirmware/Marlin/issues).
 
diff --git a/config/README.md b/config/README.md
index 609b5d4c6f..8a35573b14 100644
--- a/config/README.md
+++ b/config/README.md
@@ -1,3 +1,3 @@
 # Where have all the configurations gone?
 
-## https://github.com/MarlinFirmware/Configurations/archive/release-2.0.9.4.zip
+## https://github.com/MarlinFirmware/Configurations/archive/release-2.1.zip