diff --git a/Marlin/Configuration.h b/Marlin/Configuration.h
index ddd72d11a0..d0a49aade3 100644
--- a/Marlin/Configuration.h
+++ b/Marlin/Configuration.h
@@ -721,9 +721,12 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 // Host Keepalive
 //
 // By default Marlin will send a busy status message to the host
-// every 10 seconds when it can't accept commands.
+// every couple of seconds when it can't accept commands.
 //
 //#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
+#if DISABLED(DISABLE_HOST_KEEPALIVE)
+  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
+#endif
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/Marlin.h b/Marlin/Marlin.h
index 1499dff326..aa3d54de77 100644
--- a/Marlin/Marlin.h
+++ b/Marlin/Marlin.h
@@ -327,6 +327,10 @@ extern bool axis_homed[3]; // axis[n].is_homed
   extern float zprobe_zoffset;
 #endif
 
+#if ENABLED(HOST_KEEPALIVE_FEATURE)
+  extern uint8_t host_keepalive_interval;
+#endif
+
 #if ENABLED(PREVENT_DANGEROUS_EXTRUDE)
   extern float extrude_min_temp;
 #endif
diff --git a/Marlin/Marlin_main.cpp b/Marlin/Marlin_main.cpp
index 49bea61024..c8b9090786 100644
--- a/Marlin/Marlin_main.cpp
+++ b/Marlin/Marlin_main.cpp
@@ -155,6 +155,7 @@
  * M110 - Set the current line number
  * M111 - Set debug flags with S<mask>. See flag bits defined in Marlin.h.
  * M112 - Emergency stop
+ * M113 - Get or set the timeout interval for Host Keepalive "busy" messages
  * M114 - Output current position to serial port
  * M115 - Capabilities string
  * M117 - Display a message on the controller screen
@@ -456,6 +457,7 @@ static bool send_ok[BUFSIZE];
 
   static MarlinBusyState busy_state = NOT_BUSY;
   static millis_t next_busy_signal_ms = -1;
+  uint8_t host_keepalive_interval = DEFAULT_KEEPALIVE_INTERVAL;
   #define KEEPALIVE_STATE(n) do{ busy_state = n; }while(0)
 #else
   #define host_keepalive() ;
@@ -2297,7 +2299,7 @@ void unknown_command_error() {
           break;
       }
     }
-    next_busy_signal_ms = ms + 10000UL; // "busy: ..." message every 10s
+    next_busy_signal_ms = host_keepalive_interval ? ms + 1000UL * host_keepalive_interval : -1;
   }
 
 #endif //HOST_KEEPALIVE_FEATURE
@@ -4427,6 +4429,27 @@ inline void gcode_M111() {
  */
 inline void gcode_M112() { kill(PSTR(MSG_KILLED)); }
 
+#if ENABLED(HOST_KEEPALIVE_FEATURE)
+
+  /**
+   * M113: Get or set Host Keepalive interval (0 to disable)
+   *
+   *   S<seconds> Optional. Set the keepalive interval.
+   */
+  inline void gcode_M113() {
+    if (code_seen('S')) {
+      host_keepalive_interval = (uint8_t)code_value_short();
+      NOMORE(host_keepalive_interval, 60);
+    }
+    else {
+      SERIAL_ECHO_START;
+      SERIAL_ECHOPAIR("M113 S", (unsigned long)host_keepalive_interval);
+      SERIAL_EOL;
+    }
+  }
+
+#endif
+
 #if ENABLED(BARICUDA)
 
   #if HAS_HEATER_1
diff --git a/Marlin/example_configurations/Felix/Configuration.h b/Marlin/example_configurations/Felix/Configuration.h
index e91e927c8a..2da7f04f6d 100644
--- a/Marlin/example_configurations/Felix/Configuration.h
+++ b/Marlin/example_configurations/Felix/Configuration.h
@@ -704,9 +704,12 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 // Host Keepalive
 //
 // By default Marlin will send a busy status message to the host
-// every 10 seconds when it can't accept commands.
+// every couple of seconds when it can't accept commands.
 //
 //#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
+#if DISABLED(DISABLE_HOST_KEEPALIVE)
+  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
+#endif
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/Felix/Configuration_DUAL.h b/Marlin/example_configurations/Felix/Configuration_DUAL.h
index 29507abaad..60697ed0e8 100644
--- a/Marlin/example_configurations/Felix/Configuration_DUAL.h
+++ b/Marlin/example_configurations/Felix/Configuration_DUAL.h
@@ -701,9 +701,12 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 // Host Keepalive
 //
 // By default Marlin will send a busy status message to the host
-// every 10 seconds when it can't accept commands.
+// every couple of seconds when it can't accept commands.
 //
 //#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
+#if DISABLED(DISABLE_HOST_KEEPALIVE)
+  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
+#endif
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/Hephestos/Configuration.h b/Marlin/example_configurations/Hephestos/Configuration.h
index cac62233ff..9e0af0a329 100644
--- a/Marlin/example_configurations/Hephestos/Configuration.h
+++ b/Marlin/example_configurations/Hephestos/Configuration.h
@@ -713,9 +713,12 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = true; // set to true to invert the lo
 // Host Keepalive
 //
 // By default Marlin will send a busy status message to the host
-// every 10 seconds when it can't accept commands.
+// every couple of seconds when it can't accept commands.
 //
 //#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
+#if DISABLED(DISABLE_HOST_KEEPALIVE)
+  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
+#endif
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/Hephestos_2/Configuration.h b/Marlin/example_configurations/Hephestos_2/Configuration.h
index 9be4a5cef8..a1a89e3715 100644
--- a/Marlin/example_configurations/Hephestos_2/Configuration.h
+++ b/Marlin/example_configurations/Hephestos_2/Configuration.h
@@ -715,9 +715,12 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 // Host Keepalive
 //
 // By default Marlin will send a busy status message to the host
-// every 10 seconds when it can't accept commands.
+// every couple of seconds when it can't accept commands.
 //
 //#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
+#if DISABLED(DISABLE_HOST_KEEPALIVE)
+  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
+#endif
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/K8200/Configuration.h b/Marlin/example_configurations/K8200/Configuration.h
index 3bb350ddd4..74c5531772 100644
--- a/Marlin/example_configurations/K8200/Configuration.h
+++ b/Marlin/example_configurations/K8200/Configuration.h
@@ -738,9 +738,12 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 // Host Keepalive
 //
 // By default Marlin will send a busy status message to the host
-// every 10 seconds when it can't accept commands.
+// every couple of seconds when it can't accept commands.
 //
 //#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
+#if DISABLED(DISABLE_HOST_KEEPALIVE)
+  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
+#endif
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/RepRapWorld/Megatronics/Configuration.h b/Marlin/example_configurations/RepRapWorld/Megatronics/Configuration.h
index 487e8d8764..553c07afa5 100644
--- a/Marlin/example_configurations/RepRapWorld/Megatronics/Configuration.h
+++ b/Marlin/example_configurations/RepRapWorld/Megatronics/Configuration.h
@@ -721,9 +721,12 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 // Host Keepalive
 //
 // By default Marlin will send a busy status message to the host
-// every 10 seconds when it can't accept commands.
+// every couple of seconds when it can't accept commands.
 //
 //#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
+#if DISABLED(DISABLE_HOST_KEEPALIVE)
+  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
+#endif
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/RigidBot/Configuration.h b/Marlin/example_configurations/RigidBot/Configuration.h
index e5c98d4791..733b377cd4 100644
--- a/Marlin/example_configurations/RigidBot/Configuration.h
+++ b/Marlin/example_configurations/RigidBot/Configuration.h
@@ -716,9 +716,12 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 // Host Keepalive
 //
 // By default Marlin will send a busy status message to the host
-// every 10 seconds when it can't accept commands.
+// every couple of seconds when it can't accept commands.
 //
 //#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
+#if DISABLED(DISABLE_HOST_KEEPALIVE)
+  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
+#endif
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/SCARA/Configuration.h b/Marlin/example_configurations/SCARA/Configuration.h
index c09a7ae820..436bf22909 100644
--- a/Marlin/example_configurations/SCARA/Configuration.h
+++ b/Marlin/example_configurations/SCARA/Configuration.h
@@ -729,9 +729,12 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 // Host Keepalive
 //
 // By default Marlin will send a busy status message to the host
-// every 10 seconds when it can't accept commands.
+// every couple of seconds when it can't accept commands.
 //
 //#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
+#if DISABLED(DISABLE_HOST_KEEPALIVE)
+  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
+#endif
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/TAZ4/Configuration.h b/Marlin/example_configurations/TAZ4/Configuration.h
index 7dd94b7ae5..38e7e20cf2 100644
--- a/Marlin/example_configurations/TAZ4/Configuration.h
+++ b/Marlin/example_configurations/TAZ4/Configuration.h
@@ -742,9 +742,12 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 // Host Keepalive
 //
 // By default Marlin will send a busy status message to the host
-// every 10 seconds when it can't accept commands.
+// every couple of seconds when it can't accept commands.
 //
 //#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
+#if DISABLED(DISABLE_HOST_KEEPALIVE)
+  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
+#endif
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/WITBOX/Configuration.h b/Marlin/example_configurations/WITBOX/Configuration.h
index 6f96bbf422..fd3fa38d09 100644
--- a/Marlin/example_configurations/WITBOX/Configuration.h
+++ b/Marlin/example_configurations/WITBOX/Configuration.h
@@ -713,9 +713,12 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = true; // set to true to invert the lo
 // Host Keepalive
 //
 // By default Marlin will send a busy status message to the host
-// every 10 seconds when it can't accept commands.
+// every couple of seconds when it can't accept commands.
 //
 //#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
+#if DISABLED(DISABLE_HOST_KEEPALIVE)
+  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
+#endif
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/adafruit/ST7565/Configuration.h b/Marlin/example_configurations/adafruit/ST7565/Configuration.h
index 9620b49ffa..052008aa58 100644
--- a/Marlin/example_configurations/adafruit/ST7565/Configuration.h
+++ b/Marlin/example_configurations/adafruit/ST7565/Configuration.h
@@ -721,9 +721,12 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 // Host Keepalive
 //
 // By default Marlin will send a busy status message to the host
-// every 10 seconds when it can't accept commands.
+// every couple of seconds when it can't accept commands.
 //
 //#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
+#if DISABLED(DISABLE_HOST_KEEPALIVE)
+  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
+#endif
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/delta/biv2.5/Configuration.h b/Marlin/example_configurations/delta/biv2.5/Configuration.h
index 9c91da9d71..ce1bbf5cc3 100644
--- a/Marlin/example_configurations/delta/biv2.5/Configuration.h
+++ b/Marlin/example_configurations/delta/biv2.5/Configuration.h
@@ -843,9 +843,12 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = true; // set to true to invert the lo
 // Host Keepalive
 //
 // By default Marlin will send a busy status message to the host
-// every 10 seconds when it can't accept commands.
+// every couple of seconds when it can't accept commands.
 //
 //#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
+#if DISABLED(DISABLE_HOST_KEEPALIVE)
+  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
+#endif
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/delta/generic/Configuration.h b/Marlin/example_configurations/delta/generic/Configuration.h
index 5beb3f4b54..bc323fd5a5 100644
--- a/Marlin/example_configurations/delta/generic/Configuration.h
+++ b/Marlin/example_configurations/delta/generic/Configuration.h
@@ -843,9 +843,12 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = true; // set to true to invert the lo
 // Host Keepalive
 //
 // By default Marlin will send a busy status message to the host
-// every 10 seconds when it can't accept commands.
+// every couple of seconds when it can't accept commands.
 //
 //#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
+#if DISABLED(DISABLE_HOST_KEEPALIVE)
+  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
+#endif
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/delta/kossel_mini/Configuration.h b/Marlin/example_configurations/delta/kossel_mini/Configuration.h
index d88d12dc6e..fbaa538e96 100644
--- a/Marlin/example_configurations/delta/kossel_mini/Configuration.h
+++ b/Marlin/example_configurations/delta/kossel_mini/Configuration.h
@@ -847,9 +847,12 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 // Host Keepalive
 //
 // By default Marlin will send a busy status message to the host
-// every 10 seconds when it can't accept commands.
+// every couple of seconds when it can't accept commands.
 //
 //#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
+#if DISABLED(DISABLE_HOST_KEEPALIVE)
+  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
+#endif
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/delta/kossel_pro/Configuration.h b/Marlin/example_configurations/delta/kossel_pro/Configuration.h
index 6d769fb329..aedcf72af2 100644
--- a/Marlin/example_configurations/delta/kossel_pro/Configuration.h
+++ b/Marlin/example_configurations/delta/kossel_pro/Configuration.h
@@ -840,9 +840,12 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 // Host Keepalive
 //
 // By default Marlin will send a busy status message to the host
-// every 10 seconds when it can't accept commands.
+// every couple of seconds when it can't accept commands.
 //
 //#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
+#if DISABLED(DISABLE_HOST_KEEPALIVE)
+  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
+#endif
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/delta/kossel_xl/Configuration.h b/Marlin/example_configurations/delta/kossel_xl/Configuration.h
index e21b350e1e..cba52bf4af 100644
--- a/Marlin/example_configurations/delta/kossel_xl/Configuration.h
+++ b/Marlin/example_configurations/delta/kossel_xl/Configuration.h
@@ -757,9 +757,12 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 // Host Keepalive
 //
 // By default Marlin will send a busy status message to the host
-// every 10 seconds when it can't accept commands.
+// every couple of seconds when it can't accept commands.
 //
 //#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
+#if DISABLED(DISABLE_HOST_KEEPALIVE)
+  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
+#endif
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/makibox/Configuration.h b/Marlin/example_configurations/makibox/Configuration.h
index 6ccd700aa6..301c7d9b6f 100644
--- a/Marlin/example_configurations/makibox/Configuration.h
+++ b/Marlin/example_configurations/makibox/Configuration.h
@@ -724,9 +724,12 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = false; // set to true to invert the l
 // Host Keepalive
 //
 // By default Marlin will send a busy status message to the host
-// every 10 seconds when it can't accept commands.
+// every couple of seconds when it can't accept commands.
 //
 //#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
+#if DISABLED(DISABLE_HOST_KEEPALIVE)
+  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
+#endif
 
 //
 // M100 Free Memory Watcher
diff --git a/Marlin/example_configurations/tvrrug/Round2/Configuration.h b/Marlin/example_configurations/tvrrug/Round2/Configuration.h
index 85f2258f4d..f162ff7b60 100644
--- a/Marlin/example_configurations/tvrrug/Round2/Configuration.h
+++ b/Marlin/example_configurations/tvrrug/Round2/Configuration.h
@@ -715,9 +715,12 @@ const bool Z_MIN_PROBE_ENDSTOP_INVERTING = true; // set to true to invert the lo
 // Host Keepalive
 //
 // By default Marlin will send a busy status message to the host
-// every 10 seconds when it can't accept commands.
+// every couple of seconds when it can't accept commands.
 //
 //#define DISABLE_HOST_KEEPALIVE // Enable this option if your host doesn't like keepalive messages.
+#if DISABLED(DISABLE_HOST_KEEPALIVE)
+  #define DEFAULT_KEEPALIVE_INTERVAL 2 // Number of seconds between "busy" messages. Set with M113.
+#endif
 
 //
 // M100 Free Memory Watcher