diff --git a/Marlin/src/HAL/HAL_LPC1768/persistent_store_flash.cpp b/Marlin/src/HAL/HAL_LPC1768/persistent_store_flash.cpp
index df7cc76b03..4b02544e1b 100644
--- a/Marlin/src/HAL/HAL_LPC1768/persistent_store_flash.cpp
+++ b/Marlin/src/HAL/HAL_LPC1768/persistent_store_flash.cpp
@@ -74,7 +74,8 @@ bool PersistentStore::access_start() {
     // sector is blank so nothing stored yet
     for (int i = 0; i < EEPROM_SIZE; i++) ram_eeprom[i] = EEPROM_ERASE;
     current_slot = EEPROM_SLOTS;
-  } else {
+  }
+  else {
     // current slot is the first non blank one
     current_slot = first_nblank_loc / EEPROM_SIZE;
     uint8_t *eeprom_data = SLOT_ADDRESS(EEPROM_SECTOR, current_slot);
diff --git a/Marlin/src/HAL/HAL_STM32F1/persistent_store_flash.cpp b/Marlin/src/HAL/HAL_STM32F1/persistent_store_flash.cpp
index 43c3fbca0a..aa03474d2b 100644
--- a/Marlin/src/HAL/HAL_STM32F1/persistent_store_flash.cpp
+++ b/Marlin/src/HAL/HAL_STM32F1/persistent_store_flash.cpp
@@ -79,14 +79,15 @@ bool PersistentStore::write_data(int &pos, const uint8_t *value, const size_t si
   }
 
   // Now, write any remaining single byte
-  if (size & 1) {
+  const uint16_t odd = size & 1;
+  if (odd) {
     uint16_t temp = value[size - 1];
     status = FLASH_ProgramHalfWord(pageBase + pos + i, temp);
     if (status != FLASH_COMPLETE) return true;
   }
 
   crc16(crc, value, size);
-  pos += ((size + 1) & ~1);
+  pos += size + odd;
   return false;
 }
 
@@ -97,7 +98,7 @@ bool PersistentStore::read_data(int &pos, uint8_t* value, const size_t size, uin
     if (writing) value[i] = c;
     crc16(crc, &c, 1);
   }
-  pos += ((size + 1) & ~1);
+  pos += ((size + 1) & ~1); // i.e., size+(size&1), round up odd values
   return false;
 }
 
diff --git a/Marlin/src/module/configuration_store.cpp b/Marlin/src/module/configuration_store.cpp
index d71c97ae23..833d944447 100644
--- a/Marlin/src/module/configuration_store.cpp
+++ b/Marlin/src/module/configuration_store.cpp
@@ -384,18 +384,35 @@ void MarlinSettings::postprocess() {
 
 #if ENABLED(EEPROM_SETTINGS)
 
-  #define EEPROM_START() int eeprom_index = EEPROM_OFFSET; persistentStore.access_start()
-  #define EEPROM_FINISH() persistentStore.access_finish()
-  #define EEPROM_SKIP(VAR) eeprom_index += sizeof(VAR)
-  #define EEPROM_WRITE(VAR) persistentStore.write_data(eeprom_index, (uint8_t*)&VAR, sizeof(VAR), &working_crc)
-  #define EEPROM_READ(VAR) persistentStore.read_data(eeprom_index, (uint8_t*)&VAR, sizeof(VAR), &working_crc, !validating)
-  #define EEPROM_READ_ALWAYS(VAR) persistentStore.read_data(eeprom_index, (uint8_t*)&VAR, sizeof(VAR), &working_crc)
-  #define EEPROM_ASSERT(TST,ERR) do{ if (!(TST)) { SERIAL_ERROR_MSG(ERR); eeprom_error = true; } }while(0)
+  #define WORD_PADDED_EEPROM ENABLED(__STM32F1__, FLASH_EEPROM_EMULATION)
+
+  #if WORD_PADDED_EEPROM && ENABLED(DEBUG_EEPROM_READWRITE)
+    #define UPDATE_TEST_INDEX(VAR) (text_index += sizeof(VAR))
+  #else
+    #define UPDATE_TEST_INDEX(VAR) NOOP
+  #endif
+  #if WORD_PADDED_EEPROM
+    #define EEPROM_SKIP(VAR) do{ eeprom_index += sizeof(VAR) + (sizeof(VAR) & 1); UPDATE_TEST_INDEX(sizeof(VAR)); }while(0)
+  #else
+    #define EEPROM_SKIP(VAR) (eeprom_index += sizeof(VAR))
+  #endif
+
+  #define EEPROM_START()          int eeprom_index = EEPROM_OFFSET; persistentStore.access_start()
+  #define EEPROM_FINISH()         persistentStore.access_finish()
+  #define EEPROM_WRITE(VAR)       do{ persistentStore.write_data(eeprom_index, (uint8_t*)&VAR, sizeof(VAR), &working_crc);              UPDATE_TEST_INDEX(VAR); }while(0)
+  #define EEPROM_READ(VAR)        do{ persistentStore.read_data(eeprom_index, (uint8_t*)&VAR, sizeof(VAR), &working_crc, !validating);  UPDATE_TEST_INDEX(VAR); }while(0)
+  #define EEPROM_READ_ALWAYS(VAR) do{ persistentStore.read_data(eeprom_index, (uint8_t*)&VAR, sizeof(VAR), &working_crc);               UPDATE_TEST_INDEX(VAR); }while(0)
+  #define EEPROM_ASSERT(TST,ERR)  do{ if (!(TST)) { SERIAL_ERROR_MSG(ERR); eeprom_error = true; } }while(0)
 
   #if ENABLED(DEBUG_EEPROM_READWRITE)
+    #if WORD_PADDED_EEPROM
+      int test_index;
+    #else
+      int &test_index = eeprom_index;
+    #endif
     #define _FIELD_TEST(FIELD) \
       EEPROM_ASSERT( \
-        eeprom_error || eeprom_index == offsetof(SettingsData, FIELD) + EEPROM_OFFSET, \
+        eeprom_error || test_index == offsetof(SettingsData, FIELD) + EEPROM_OFFSET, \
         "Field " STRINGIFY(FIELD) " mismatch." \
       )
   #else