diff --git a/Marlin/src/inc/SanityCheck.h b/Marlin/src/inc/SanityCheck.h
index c1c75f0422..f1ea163952 100644
--- a/Marlin/src/inc/SanityCheck.h
+++ b/Marlin/src/inc/SanityCheck.h
@@ -1009,6 +1009,13 @@ static_assert(Y_MAX_LENGTH >= Y_BED_SIZE, "Movement bounds (Y_MIN_POS, Y_MAX_POS
   #endif
 #endif
 
+/**
+ * Junction deviation is not compatible with kinematic systems.
+ */
+#if ENABLED(JUNCTION_DEVIATION) && IS_KINEMATIC
+  #error "Junction deviation is only compatible with Cartesians."
+#endif
+
 /**
  * Probes
  */