diff --git a/Marlin/src/Marlin.cpp b/Marlin/src/Marlin.cpp
index 177e424f2d..d9c5c9b457 100644
--- a/Marlin/src/Marlin.cpp
+++ b/Marlin/src/Marlin.cpp
@@ -428,8 +428,10 @@ void manage_inactivity(bool ignore_stepper_queue/*=false*/) {
   #endif
 
   #if ENABLED(EXTRUDER_RUNOUT_PREVENT)
-    if (ELAPSED(ms, gcode.previous_cmd_ms + (EXTRUDER_RUNOUT_SECONDS) * 1000UL)
-      && thermalManager.degHotend(active_extruder) > EXTRUDER_RUNOUT_MINTEMP) {
+    if (thermalManager.degHotend(active_extruder) > EXTRUDER_RUNOUT_MINTEMP
+      && ELAPSED(ms, gcode.previous_cmd_ms + (EXTRUDER_RUNOUT_SECONDS) * 1000UL)
+      && !planner.blocks_queued()
+    ) {
       #if ENABLED(SWITCHING_EXTRUDER)
         const bool oldstatus = E0_ENABLE_READ;
         enable_E0();